Dr. Wallace is the Fred C. Andersen Professor of Medicine at Mayo Clinic.
He received his medical degree from Duke University School of Medicine in 1992. He completed a residency program in Internal Medicine in 1995 and a fellowship in Gastroenterology and Hepatology in 1998 at the Harvard Medical School/Brigham and Women’s Hospital in Boston, Massachusetts and a Master’s in Public Health with a focus on clinical research at the Harvard School of Public Health, and research fellowship in advanced imaging technology at Massachusett’s Institute of Technology.
Dr. Wallace completed an advanced endoscopy fellowship in Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) in 1999 at the Medical University of South Carolina under Dr. Peter Cotton and Robert Hawes.
He joined the Mayo Clinic in 2003 advancing to the rank of full professor in 2007, to Chair of the Division in 2010, and endowed professor (John C. Andersen Professorship) in 2019. Dr. Wallace has served multiple roles for the international GI societies such as the AGA, ASGE and ACG including Associate Editor for Gastroenterology 2006-09, National mentor of the year (AGA and ASGE) and chair of both ASGE and the World Endoscopy Organization (WEO) committee on Artificial Intelligence. From 2015-2022, he was Editor in Chief of Gastrointestinal Endoscopy, advancing that journal to the # 1 rank in its category.
His clinical and research interests focus on advanced imaging technologies for early gastrointestinal cancer detection and therapy including fundamental research in tissue spectroscopy, narrow band imaging, optical coherence tomography, and AI-computer vision systems. He holds NIH RO1 funding in Optical Coherence Tomography (OCT) technologies for early esophageal cancer, and had developed and published AI tools to advance colon polyp detection which led to the U.S. F.D.A. approval of the first AI colonoscopy systems, G.I. Genus. He current is co-investigator on an NIH funded RO1 grant to develop AI tools to improve detection of early pancreatic cancer in patients with cystic neoplasia of the pancreas. He has published more than 450 peer-reviewed articles, which have been cited more than 28,000 times, and carries an H-Index of 93, among the top 1% of academics worldwide.
Regarding management and consulting expertise, he served as Chair of Gastroenterology and Hepatology at Sheik Shakhbout Medical City, in partnership with Mayo Clinic, in Abu Dhabi, UAE from 2020-2024. During that time, he built a premier destination medical center for complex Gastroenterology and Hepatology in the Middle East, increased volumes, revenue and financial performance more than 100%. In 2022, he became director of Outpatient Practice where he has similarly increased volumes, reduced no-show rates, optimized patient journey flow, and improved patient satisfaction across SSMC.
Likewise, he led the SSMC Center for Medical Simulation and Innovation, building a premier simulation center, administering internal and external simulation based medical training programs, and partnering with medical device companies to foster innovation and development of new technologies.
Finally, he led the SSMC Artificial Intelligence committee, responsible for identification and implementation of AI technologies to enhance patient care including GI Genius, and AIDOC technologies to enhance endoscopic and radiologic imaging accuracy and efficiency, while also developing AI policies to ensure safe, accurate, and patient focused uses of AI in healthcare.